We don't have special requirements for the default configuration of Hand2Note:
http://hand2note.com/Help/Index/SystemRequirements
But if you intend to use very complicated Dynamic HUDs then GPU and amount of RAM will be important.
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Thank you for contacting Hand2Note support.
Unfortunately, we did not test the performance of our software on AMD processors, but we have feedback from our users who claim that Hand2Note shows greater performance on Intel processors. In addition, the frequency and amount of RAM are definitely very important for performance.
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Unfortunately, we did not test the performance of our software on AMD processors, but we have feedback from our users who claim that Hand2Note shows greater performance on Intel processors and there are some problems with Simultaneous Multithreading (SMT) on an AMD CPU. So we always recommend Intel.